Fig. 2

Comparison of lung microbial compositions among non-infected mice and mice infected with SARS-CoV-2 Wuhan or Omicron. (a) Relative abundances of bacterial families in the lungs of the experimental mice. (b–d) ACE index (b), Shannon index (c), and F/B ratio (d) of the lung microbiota of non-infected mice and mice infected with SARS-CoV-2 (Wuhan or Omicron, n = 4 mice each group). (e–g) ACE index (e), Shannon index (f), and F/B ratio (g) of the lung microbiota in non-infected mice, mice infected with SARS-CoV-2 Wuhan, and mice infected with SARS-CoV-2 Omicron. (h–j) Bacteria with LDA scores > 3.5 in pairwise comparisons between non-infected mice and mice infected with SARS-CoV-2 Wuhan (h), non-infected mice and mice infected with SARS-CoV-2 Omicron (i), and mice infected with SARS-CoV-2 Wuhan and mice infected with SARS-CoV-2 Omicron (j). (k–p) Relative abundances of E. coli group (k), Erysieplotrichaceae_f (l), B. pseudolongum group (m), Kineothrix_g (n), Eubacterium_g23 (o), and Eubacterium_g8 (p) among the lung microbiota of experimental mice. Data in b–g and k–p were analyzed using the Wilcoxon rank-sum test