Evaluation of the protective effects of Spirulina platensis against cyclophosphamide-induced genotoxicity

Table 5 Effects of Spirulina platensis powder followed by cyclophosphamide administration on bone marrow cells

Mice	Normal Control		Positive Control		SP 37.5 + C		SP 75 + C		SP 150 + C
Mice	MnPCEs/5000 PCEs	PCEs%	MnPCEs/5000 PCEs	PCEs%	MnPCEs/5000 PCEs	PCEs%	MnPCEs/5000 PCEs	PCEs%	MnPCEs/5000 PCEs	PCEs%
1	5	51.64	17	43.14	13	44.72	8	43.73	5	41.87
2	6	46.42	9	43.08	15	46.80	6	45.96	6	45.94
3	5	56.61	17	39.77	15	42.47	10	45.52	6	45.08
4	5	46.43	19	41.77	14	44.93	6	42.24	7	42.42
5	4	41.04	15	44.43	9	47.39	5	45.03	5	45.63
M ± SEM	5.00 ± 0.32	48.43 ± 3.10	15.40 ± 1.72^####	42.44 ± 0.79^#	13.22 ± 1.11	45.26 ± 0.87	7.00 ± 0.89^***	44.50 ± 1.41	5.80 ± 0.37^****	44.19 ± 0.85

Five batches of 5 mice were formed. The normal control was treated with distilled water; the positive control was given cyclophosphamide at 100 mg/kg; SP 37.5 + C; SP 75 + C; and SP 150 + C were pretreated with total extract at doses of 37.5, 75, and 150 mg/kg and subsequently given cyclophosphamide at 100 mg/kg. # p < 0.05 # # # # p < 0.0001 (compared to the normal control); ***p < 0.001 ****p < 0.0001 (compared to the positive control)
PCE = micronucleus in polychromatic erythrocytes; PCE = polychromatic erythrocytes; NCE = normochromatic erythrocytes

ISSN: 2233-7660