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Fig. 1 | Laboratory Animal Research

Fig. 1

From: Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway

Fig. 1

The STAT1/IRF1 pathway is associated with LPS-induced ALI in mice. A RNA-seq data presenting comparisons of the expression of several genes, including IRF1 family genes, between the control and LPS groups of mouse lung tissue lysates (n = 2 per group). B Expression of IRF family genes was measured as FPKM values. C Western blotting of IRF1 and IRF7 in mouse lung tissue (upper) and their densitometric ratios against β-actin (bottom) (n = 3 per group). *p < 0.05 compared with the control group. ns: not significant. D Confocal images of immunostaining for IRF1 (green) in BAL cells. Scale bar, 10 μm (n = 2 per group). E Western blotting of pSTAT1 (Tyr701), pSTAT1 (Ser727), total STAT1, and β-actin in mouse lung tissue (upper) and their densitometric ratios against STAT1 (bottom) (n = 3 per group). The data are presented as mean ± SD

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Laboratory Animal Research

ISSN: 2233-7660